Intensification of oxygen-dependent biotransformations catalyzed by immobilized enzymes

Oxidative biotransformations find a prominent role in the fine chemical industry and valorization of renewable feedstocks. Implementation oxygen-dependent reactions faces some challenges across scales at different levels development. First, fruitful development enzyme candidates identification reaction possibilities is not consonance with implementation process engineering. Second, engineering complex interplay kinetic, oxygen transfer stability. Third, given advances synergic fields such as molecular biology, chemistry, material sciences, (micro)process engineering, an interdisciplinary assembly from consistent discipline around heterogeneous biocatalyst would be strategic value. We show design active robust immobilized catalysts to applied (continuous) intensified processes. A framework based on joint catalyst reactor will discussed for optimization involved.